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Posts: 25
Registered:
June 2006
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[bnmc-announce] BNMC Seminar: In vitro transcriptional circuits: design, dynamics, and robustness
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Tue, 18 November 2008 11:36
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Biological Network Modeling Center Seminar: "In vitro transcriptional
circuits: design, dynamics, and robustness"
Erik Winfree
Associate Professor of Computer Science and Computation and Neural Systems
Caltech
Thursday, November 20, 2008
2:00PM - 3:00PM
Beckman Institute Auditorium
(refreshments at 1:45 in the lobby)
Synthetic biochemical circuits both provide an opportunity to embed control
logic within chemical systems for technological applications and provide a
platform for probing our understanding of general principles for biochemical
circuits. We have developed a general approach to the construction of in
vitro biochemical circuits based on the transcription and degradation of RNA
molecules.
Consisting of just DNA templates and two enzymes, in principle arbitrary
circuits can be systematically constructed, displaying a rich variety of
dynamical and computational behavior. We have experimentally demonstrated
individual transcriptional switches, a bistable network, and several
oscillating circuits. In doing so, we have encountered a number of
unexpected difficulties -- deviations from ideal circuit behavior -- that
help frame the critical questions of how to model and design robust
biochemical systems.
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